Mediterranean Diet, Trimethylamine N-oxide (TMAO) and Anti-oxidants in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 主要终点
- Adherence to Mediterranean Diet by Predimed Questionnaire
研究概览
简要总结
Trimethylamine N-oxide (TMAO) is a small organic compound naturally present in fish and seefood or generated by the bacterial breakdown of dietary phosphatidylcholine and carnitine-containing foods within the human gut microbiome. Elevated serum TMAO was previously reported to be associated with an elevated risk for cardiovascular events.
Aim of this study was to investigate the association between plasma levels of TMAO with the Mediterranean diet in a cohort of healthy adults.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subjects of both gender
排除标准
- •age>65 years
- •> BMI 30 kg/m2
- •vegetarians
- •gastrointestinal diseases or complaints
- •chronic illnesses or other metabolic diseases (including trimethylaminuria)
- •abnormal blood chemistry values indicative of organ dysfunctions
- •nutritional supplements, antibiotics or probiotics within 2 months of recruitment
结局指标
主要结局
Adherence to Mediterranean Diet by Predimed Questionnaire
时间窗: September 2016 to December 2016
Validated 14-item tool of adherence to the Mediterranean diet, with three categories of adherence (≤5, low adherence, 6-9, average adherence and ≥10 points, high adherence)
Trimethylamine N-oxide plasma levels
时间窗: September 2016 to December 2016
ultra high-performance liquid chromatography
次要结局
- cardiovascular risk(September 2016 to December 2016)
研究者
Prof. Silvia Savastano
Researcher/Adjunct Professor
Federico II University