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临床试验/NCT06702930
NCT06702930已完成不适用

The Effects of Morning vs. Evening High-intensity Interval Exercise on the Magnitude of the Morning Blood Pressure Surge

University of Guelph2 个研究点 分布在 1 个国家目标入组 31 人开始时间: 2020年1月28日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
31
试验地点
2
主要终点
Morning blood pressure surge

研究概览

简要总结

The goal of this clinical trial was to assess the effects of morning vs. evening high-intensity interval exercise on the magnitude of the morning blood pressure surge in young healthy adults. The main questions it aimed to answer were:

  • Does the timing of high-intensity interval exercise modulate the magnitude of the morning blood pressure surge?
  • Do sex differences exist?

Participants came in and completed a bout of high-intensity interval exercise in the morning (8-10 am) and evening (5-7 pm) as well as a no exercise control, and ambulatory blood pressure was assessed for 24 hours afterwards.

详细描述

Introductory Visit:

Participants came in for 4 visits. The first visit was an introductory visit where chronotype, eligibility for exercise, and anthropometrics were measured. This was followed by a maximal incremental exercise test to determine aerobic capacity (i.e., V̇O2peak) on a cycle ergometer, and instrumentation of an ambulatory blood pressure monitor for familiarization during daily activities and sleep.

Intervention Visits:

Three intervention visits (control, morning exercise, and evening exercise) were completed. The order was randomized using and each visit was separated by a minimum of 36 hours. Each intervention visit began by obtaining the participant's resting blood pressure and heart rate and ended with the instrumentation of the ambulatory blood pressure monitor. No exercise was performed during the control visit. The morning exercise visit included a bout of high-intensity interval exercise between 8-10 am and the evening exercise visit included a bout of high-intensity interval exercise between 5-7 pm. The high-intensity interval exercise protocol consisted of a light intensity, 3-minute warm-up at 15% peak power followed by ten 1-minute work intervals at 80% of peak power, with each interval separated by 1-minute rest intervals at 15% peak power. A 3-minute cool down was performed at 15% peak power.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Between 18-50 years of age.
  • No history of known disease.
  • None smokers.
  • No use of chronic medications other than oral contraceptives.

排除标准

  • <18 years of age.
  • >50 years of age.
  • Cardiovascular disease.
  • Metabolic disease.
  • History of smoking (within the past 3 months).
  • Chronic medications (other than oral contraceptives).

结局指标

主要结局

Morning blood pressure surge

时间窗: Through study completion, an average of 4 weeks.

The difference between morning blood pressure (the mean of the 4 blood pressure readings after awakening) and sleep-trough blood pressure (the mean of the lowest blood pressure during sleep and two adjacent blood pressure readings).

次要结局

  • Nighttime blood pressure dip(Through study completion, an average of 4 weeks.)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Philip Millar

Associate Professor

University of Guelph

研究点 (2)

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