ISRCTN35866380已完成不适用
Voriconazole study: treatment of chronic endobronchial Aspergillus infection with voriconazole in patients with cystic fibrosis
Erasmus Medical Centre (The Netherlands)0 个研究点目标入组 20 人开始时间: 2005年12月19日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Confirmed diagnosis of CF (documented by positive sweat test and/or by positive rectal current measurement, and/or genotype consistent with CF, two positive CF mutations, accompanied with two or more clinical features consistent with the CF phenotype)
- •2. At least three positive cultures for Aspergillus in the two years prior to the study
- •3. Positive galactomannan test at the start of the study
- •4. Older than 2 years of age
排除标准
- •1. Allergy to voriconazole
- •2. Use of drugs contraindicating use of voriconazole:
- •2.1. Terfanadine
- •2.2. Astemizol
- •2.3. Cisapride
- •2.4. Pimozide
- •2.5. Kinidine
- •2.6. Rifampicide
- •2.7. Carbamazepine
- •2.8. Phenobarbital
- •2.9. Ergotamine alkaloiden
- •2.10. Sirolimus
- •3. Use of liposomal amphotericine B
- •4. Use of high dose prednisone
- •5. Inability to produce sputum
- •6. Poor compliance
- •7. Pregnancy
研究者
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