Significance of Drain Amylase Levels After Pancreaticoduodenectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 600
- 主要终点
- postoperative pancreatic fistula
研究概览
简要总结
This study investigated the impact of highest drain fluid amylase (DFA) level on postoperative pancreatic fistula (POPF) severity and outcomes of patients undergoing pancreaticoduodenectomy (PD) with POPF. Patient demographics of biochemical POPF and clinically relevant POPF (CR-POPF) were compared. Predictive factors were assessed using binary logistic regression. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value of highest DFA (beyond 3 days post-PD). The investigators compared length of hospital stay, surgical mortality rates, and need for postoperative interventions by highest DFA level.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •underwent PD from October 2010 to September 2018 in our institution
排除标准
- •younger than 20 years of age
- •clinical information was unavailable due to private or legal issues
- •receiving PD without pancreaticojejunostomy
结局指标
主要结局
postoperative pancreatic fistula
时间窗: through study completion, an average of 2 month
fluid output of any measureable volume via an operatively placed drain with amylase activity greater than 3 times the upper normal serum value
次要结局
- length of hospital stay(through study completion, an average of 2 month)
- 30-day mortality rates(30 day)
- postoperative interventions(through study completion, an average of 2 month)