Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome: Study Conducted in the Hauts-de-France
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Correlation between endometrial cancer and predictif factors
研究概览
简要总结
Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome.
Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen.
Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Lynch Syndrome Diagnosis at University Hospital
- •Alive at study time
- •Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis
- •Case group :
- •No cancer before endometrial cancer diagnosis
- •Control group :
- •No endometrial cancer developped
- •Free cancer women at Lynch Syndrome diagnosis
排除标准
- •Refusing to participate
- •Poor understanding of the French language
- •Other cancer diagnosed before endometrial cancer
- •Hysterectomy before lynch diagnosis for free cancer women
结局指标
主要结局
Correlation between endometrial cancer and predictif factors
时间窗: Baseline
Endometrial cancer (yes/no) and explicative variable: Diabetes before endometrial cancer or Lynch syndrome diagnosis; Smoking ; Maximal Weight ; Age at menarche; Parity ; Age at first birth ; Contraceptive use.
次要结局
- Correlation between endometrial cancer and predictif factors in post menopausal woman(Baseline)