EUCTR2017-004478-32-DK进行中（未招募）1 期
The effect of metoprolol on myocardial function, hemodynamics and heart failure symptoms in patients with hypertrophic obstructive cardiomyopathy - TEMPO
Aarhus University Hospital0 个研究点目标入组 32 人开始时间: 2017年12月14日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •- Informed consent
- •- Symptomatic patients, who fits the criteria for HCM ( wall thickness = 15 mm in one or more myocardial segments that is not explained by loading conditions.)
- •- LVOTG > 30 mmHg at rest and/or >50 mmHg at Valsalva’s maneuver or exercise
- •- = NYHA II
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 15
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 17
排除标准
- •- Age < 18 years
- •- Know allergi to trial medication
- •- Contraindications to beta-blocker treatment
- •- Contraindications to Magnetic resonance scan including the contrast agent gadolineum
- •- Female patients who are pregnant (positive Plasma-HCG), nursing, or of childbearing potential while not practicing effective chemical contraceptive methods (i.e. oral, implanted, injectable or transdermal contraceptive hormones; intrauterine device)
- •- Pacemaker
- •- Treatment with Cordarone
- •- Atrial fibrillation/flutter at the time of examination
- •- Bradycardia < 49 beats/min
- •- Systolic blood pressure < 100 mmHg
- •- Trifasicular block
- •- Previous TASH (transcoronary ablation of septum hypertrophy) or myectomy
- •- Current abuse of alcohol and drugs
- •- Significant comorbidity or issue that makes the patient unsuitable fpr participation, judged by the investigator
- •- Patients who cannot give valid consent (e.g. mental illness or dementia)
- •- Patients who do not understand danish
研究者
相似试验
已完成
3 期
Perioperative ischaemic evaluation trialPerioperative cardiac morbidity and mortality within 30 days of surgerySurgery - Other surgeryACTRN12605000308695MediClin Pty Ltd10,000
已完成
2 期
The Effect of Metoprolol in Patients With Hypertrophic Obstructive Cardiomyopathy.Hypertrophic CardiomyopathyNCT03532802Steen Hvitfeldt Poulsen30
尚未招募
3 期
The Effects of Metoprolol on the Cardiorespiratory Response to orotracheal extubation: prospective, randomized, double-blind, placebo-controlled clinical trialHemodynamic PhenomenaE02.897RBR-3xk4qkqHospital de Base do Distrito Federal
已完成
不适用
The effect of propofol on cardiac function usin Tissue Doppler ImagingKCT0000635Konkuk University Medical Center38
已完成
2 期
Effect of Metoprolol on Thalassemia CardiomyopathyB ThalassemiaNCT01863173Shiraz University of Medical Sciences45