Diagnostic and Prognostic Value of New Quick Tests of Action Slowing in Stroke and in Cognitive Neurodegenerative Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 129
- 试验地点
- 2
- 主要终点
- Value of the speed of the action with the 'RT Componential Analysis of Action Speed' battery in all patients
研究概览
简要总结
A large series of recent studies have documented the frequency of the slowing of the action in brain diseases, especially vascular and neurodegenerative diseases. In stroke, the predictive value of action slowing at the acute phase for predicting post-stroke functional outcome remains poorly investigated. In neurodegenerative diseases, the diagnostic relevance of the slowing at the prodromal stage remains unknown and this diagnostic requires new tests. Finally, in terms of anatomical determinants, few studies have studied the determinants of action slowing. The objectives of this project are to Determine the diagnostic and prognostic value of action slowing assessed with new quick tests in patients with acute stroke (Neurovascular Unit) and cognitive neurodegenerative disorders (Alzheimer Disease (AD), Lewy Body disease (LBD), Fronto Temporal lobar degeneration (FTLD), Cortico Basal Degeneration (CBD) and Progressive Supra Nuclear Palsy (PSNP)) and to define the lesion determinants with VBM and VLSM
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients between 40 and 85 years old,
- •French native language,
- •Social Security affiliation.
- •University Memory Clinic for: Mild severity disorder (MMSE> 19) or major severity disorder related to AD : Albert 2011 criteria ; McKhann 2011
- •to MCL according to McKeith criteria
- •to FTLD according to Rascovsky 2011 criteria
- •BBD according to Armstrong's criteria
- •related to PSP according to Höglinger criteria
排除标准
- •Mental retardation or guardianship
- •Previously diagnosed dementia
- •Other current or past brain condition
- •severe head trauma
- •epilepsy prior to stroke still requiring previous treatment
- •Parkinson disease, multiple sclerosis...
- •brain tumor or brain radiation therapy
- •Current or past schizophrenia or psychosis
- •Active or past psychiatric disorders requiring a stay> 2 days in a specialized environment
- •Contra indication to MRI
- •Comorbidity with life expectancy <1 year
- •Comorbidity affecting cognition in particular:
- •Alcohol (> 3 glasses / day) or history of alcohol withdrawal syndrome
- •opiate or cocaine addiction or opiate withdrawal syndrome
- •renal failure (dialysis or creatinine clearance <30)
- •hepatic failure (spontaneous INR> 1.5 or PT <60%)
- •respiratory failure requiring oxygen therapy
- •heart failure (orthopnea> 2 pillows)
- •persistent vigilance disturbances (NIHSS1a score ≤1)
- •cancer with paraneoplastic syndrome
- •treatment with gold salts, D Penicillamine or other treatment with cognitive effect
- •Patient under guardianship or curators or private under public law
- •Pregnant and / or lactating wom
结局指标
主要结局
Value of the speed of the action with the 'RT Componential Analysis of Action Speed' battery in all patients
时间窗: 12 months
RT Componential Analysis of Action Speed
次要结局
- Speed values of action measured in all patients with the "MindPlus" battery in all patients(12 months)