Prospective Celiac Disease Diagnosis Evaluation (ProCeDE). - ProCeDE

European Society of Peadiatric Gastroenterology, Hepatology and Nutrition0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Consecutive children (age > 6 months - < 18.0 years) with a high degree suspicion for celiac disease consuming a gluten containing diet:
•- A child with clinical symptoms indicative of celiac disease plus a positive test of any titer specific height for celiac disease specific antibodies (TG2, EMA, DGP- cave positive DGP-titer alone does not quanlify the patient for biopsy!) or
•- A child with an increased risk for celiac disease such as having relatives of celiac disease patients or patients with diseases associated with celiac disease (Hashimoto Thyroiditis, Type I DM, Down's symdrome) with no or mild unspecific clinical symptoms but with a positive test for celiac disease specific antibodies (positive test for TG2 and/or positive EMA (>1:10)).

•- Patient with symptoms that may indicate celiac disease, but negative celiac disease specific antibodies (TG2 or EMA), but normal IgA.
•- Patient without symptoms, and negative celiac specific antibodies (TG2 and EMA)
•- Malignancy
•- Serious chronic infections such as HIV or tuberculosis or congenital immunodeficiency
•- Contraindications for endoscopy/biopsies
•- Parents did not sign consent form
•- Parents can not read/are not able to understand to give informed consent

发起方

European Society of Peadiatric Gastroenterology, Hepatology and Nutrition