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临床试验/NCT07451327
NCT07451327已完成不适用

Effect of Adding Magnesium Sulphate to Bupivacaine in Laparoscopic Periportal Preperitoneal Local Infiltration in Laparoscopic Sleeve Gastrectomy

Alexandria University1 个研究点 分布在 1 个国家目标入组 68 人开始时间: 2024年5月1日最近更新:
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
68
试验地点
1
主要终点
quality of pain control using vas score

研究概览

简要总结

EFFECT OF ADDING MAGNESIUM SULPHATE TO BUPIVACAINE IN LAPAROSCOPIC PERIPORTAL PREPERITONEAL LOCAL INFILTRATION IN LAPAROSCOPIC SLEEVE GASTRECTOMY Our study shows that adding magnesium to the block will prolong duration of analgesia and decrease total amount of analgesia needed will decrease time of stay at PACU and stay at hospital

详细描述

Obesity isn't just a cosmetic issue, it is a medical condition, sometimes considered a disease in which excess body fat has accumulated to an extent that can potentially have negative effects on health, The increasing prevalence of obesity has become a significant concern worldwide. It increases the risk of many other diseases and health problems that include heart diseases, diabetes, high blood pressure, fatty liver, apnea, even certain cancers.

Bariatric surgery has become the most effective way to lose weight. Health care providers recommend bariatric surgery if other conservative weight loss methods have failed. Surgical weight loss operations have been performed over the last 20 years. Bariatric surgery procedures include gastric bypass, gastric band, duodenal switch and sleeve gastrectomy, Laparoscopic sleeve gastrectomy (LSG) is an effective procedure for weight loss. It has become the most commonly performed bariatric surgery with low morbidity without long term malabsorptive risks.

In patients undergoing LSG, postoperative pain management is essential for reducing complications due to excessive opioid use, early mobilization and shortening hospital stays, Multimodal analgesia seems to be the gold standard in the treatment of acute pain, particularly for bariatric surgery patients who frequently have numerous coexisting conditions, one of these conditions is obstructive sleep apnea (OSA) which is common among obese individuals, making safe analgesic treatment a bit challenging.

Perioperative multimodal analgesia uses a combination of analgesic medications that act on various sites and pathways in an additive or synergistic manner to achieve pain relief with minimal or no opioid consumption, The clinical practice trends are now shifting towards opioid sparing anaesthesia.

Local infiltration analgesia is widely used as a component of multimodal analgesia. It involves the injection of a local anaesthetic near the surgical incision site to provide analgesia. Periportal preperitoneal local anaesthetic infiltration is a technique that was first described by Dean et al, for pain relief in laparoscopic hernia repair and is now gaining popularity.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Health Services Research
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
18 Hours 至 50 Hours(Child)
性别
All
接受健康志愿者

入选标准

  • • Age: 18-50 years of age.
  • American Society of Anesthesiologists (ASA) physical status class I-III
  • Body mass index 30-50 kg/m².

排除标准

  • Severe cardiac disorder
  • Chronic renal failure
  • Liver cirrhosis
  • Allergy to bupivacaine
  • Patients with history of chronic opioid consumption

研究组 & 干预措施

group c who received bupivacaine in periportal preperitoneal local infiltration

Experimental

who received bupivacaine in periportal preperitoneal local infiltration

干预措施: ADDING MAGNESIUM SULPHATE TO BUPIVACAINE IN LAPAROSCOPIC PERIPORTAL PREPERITONEAL LOCAL INFILTRATION IN LAPAROSCOPIC SLEEVE GASTRECTOMY (Drug)

group m who received bupivacaine and magnesium in periportal preperitoneal local infiltration

Experimental

who received bupivacaine and magnesium in periportal preperitoneal local infiltration

干预措施: ADDING MAGNESIUM SULPHATE TO BUPIVACAINE IN LAPAROSCOPIC PERIPORTAL PREPERITONEAL LOCAL INFILTRATION IN LAPAROSCOPIC SLEEVE GASTRECTOMY (Drug)

结局指标

主要结局

quality of pain control using vas score

时间窗: 24 hours postoperatively

postoperative pain will be assessed using visual analog scale (VAS) where 0 indicates no pain and 10 indicates worst pain

次要结局

  • patient satisfaction(24 hours postoperatively)
  • time to first postoperative analgesic requirement(24hours postoperatively)
  • total amount of morphine consumption(24hours postoperatively)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mohamed Elsayed

assistant lecturer ,alexandria university

Alexandria University

研究点 (1)

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