Comparison of Effects on Hemodynamics Between Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients With High Shock Index
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Systolic blood pressure difference compared with baseline after 10 minutes
研究概览
简要总结
In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.
详细描述
In trauma patients, rapid sequence intubation is recommended. The drug of choice, however, has been debated. One cohort comparative study showed ketamine had benefit in hemodynamics compared to etomidate in trauma patients. One observational study showed in high shock index patients, ketamine showed maintain systolic blood pressure. And other retrospective showed less clinical hypotension was less in ketamine. However there is no randomized controlled study comparing ketamine and etomidate in trauma patients. The purpose of this study is comparing the effects of hemodynamics between ketamine and etomidate in high shock index trauma patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
盲法说明
open label
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 19~70
- •Shock index ≥ 0.9
- •Patients who need intubation regarding to Ajou trauma center protocol
排除标准
- •during CPR
- •CPR before hospital arrival
- •Severe head trauma
- •Steroid intake history
研究组 & 干预措施
Etomidate
The induction agent of rapid sequence intubation is etomidate. 0.2 mg/kg
干预措施: Etomidate Injection 0.2 mg/kg (Drug)
Ketamine
The induction agent of rapid sequence intubation is ketamine. 2 mg/kg
干预措施: Ketamine injection 2 mg/kg (Drug)
结局指标
主要结局
Systolic blood pressure difference compared with baseline after 10 minutes
时间窗: 13 minutes
Systolic blood pressure 10 minutes after induction agent injection - baseline systolic blood pressure mmHg Positive or zero value means good result. Negative value means poor result.
次要结局
- Incidence of hypotension(25 minutes)
- Intubating condition(5 minutes)
- Incidence of hypertension(25 miinutes)
研究者
In-kyong Yi
Clinical assistant professor
Ajou University School of Medicine