Experimental Study of the Neural Bases of Phantom Pain After Amputation and Their Modification by Proprioceptive Training: MRI Study of the Brain and Spinal Cord
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 75
- 主要终点
- Change in brain activity, measured through fMRI, following proprioceptive training
研究概览
简要总结
The amputation of a limb results in chronic pain associated with the lost limb in the majority of patients, which persists over time. Despite a large number of studies conducted in an attempt to elucidate the neural basis of phantom pain, these are still not elucidated and current treatments often fail to relieve patients' pain.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Between 18 and 65 years old
- •For the "amputees with phantom pain" group: patients who have been amputated for more than 2 years and have chronic phantom pain
- •For the "amputees without phantom pain" group: patients who have been amputated for more than 2 years and do not have chronic phantom pain
- •For the "healthy participants" group: healthy participants with no neurological history
排除标准
- •Clinically significant pathology (gastrointestinal, renal, hepatic, endocrine, cardiovascular or respiratory)
- •Progressive psychiatric or neurological pathology
- •On psychotropic medication
- •Pregnant or nursing woman
- •Inadequate level of French language
结局指标
主要结局
Change in brain activity, measured through fMRI, following proprioceptive training
时间窗: Up to 3 months
Brain activity (BOLD hemodynamic response) will be measured via fMRI before and after proprioceptive training sessions.
Change in spinal cord activity, measured through spinal fMRI, following proprioceptive training
时间窗: Up to 3 months
Spinal cord activity (BOLD hemodynamic response) will be measured via spinal fMRI before and after proprioceptive training sessions.
次要结局
未报告次要终点