Searching for Explanations for Cryptogenic Stroke in the<br>Young: Revealing the Etiology, Triggers, and Outcome - SECRETO

Helsinki University Central Hospital0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年2月28日

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•Ischemic stroke
•Age 18 - 49 years
•Hospitalized due to first-ever imaging postive ischemic stroke without cause found after complete and timely minimum diagnostic testing

•Baseline mandatory minimum tests not obtained in the first week following stroke onset,
•a. Brain MRI
•b. Routine blood tests, including complete blood count with differential, CRP, fasting glucose,
•creatinine, aPTT, INR, total cholesterol, LDL-cholesterol, HDL-cholesterol, HbA1C, and
•hemoglobin electrophoresis in individuals of African origin
•Other baseline mandatory minimum tests not obtained within the first two weeks following
•stroke onset, including:
•a. Imaging of cervicocephalic arteries by CTA, MRA, or DSA
•b. Transesophageal (highly recommended) and/or transthoracic echocardiography (N.B. Early
•screening of venous thrombosis in the lower extremities is highly recommended in patients
•with established right-to-left shunt)
•c. 24-hour Holter monitoring (or continuous in-hospital ECG monitoring for at least 24 h)
•d. Screening for thrombophilia, including anticardiolipin antibodies, lupus anticoagulant, anti-β2-
•glycoprotein antibodies, factor V mutation (or aPC resistency ruled out), factor II mutation,
•homocysteine, antithrombin III, protein C, and protein S. It is highly recommended to retest
•any abnormal finding >12 weeks from the initial testing or >4 weeks after cessation of
•anticoagulation at any later time point.

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