KCT0000624尚未招募未知
A Multi-center, Phase IV Open-label Study to Evaluate the Effects of Carvedilol in Patients with Severe Portal Hypertension and Non-response or Poor Compliance to Propranolol
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 20(Year) 至 70(Year)（—）
- 性别
- All
入选标准
- •(1) nonrresponder to propranolol used in patients enrolled A Randomized, Multi-center, Phase IV Open-label Study (Cris KCT0000102) to Evaluate the Long-term Effect of Carvedilol versus Propranolol on Reduction in Portal Pressure in Patients with Cirrhosis(CARPE study) at end of treatment. Patients within 6 months after the end of CARPE study
- •(2)Poor compliance to propranolol in CARPE study. Patients within 6 months with after the end of CARPE study
排除标准
- •(1) systolic blood pressure < 90 mmHg, baseline heart rate < 55/min
- •(2) refractory ascites, hepatic encephalopathy, hepatorenal syndrome
- •(3) hepatocellular carcinoma
- •(4) presence of severe systemic illness
- •(5) history of gastric variceal hemorrhage
- •(6) contraindication of beta-blocker
- •(7) serum jaundice > 10 mg/dL
- •(8) srum creatinine = 1.2 mg/dL
- •(9) history of shunt or TIPS
- •(11) pregnancy, lactation
- •(12) allergy to beta-blocker or alpha-blocker
- •(13) unwilling to sign inform consent
- •(14) Clinical investigator have determined that patient is difficult to perform the clinical trial.
研究者
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