TMS Modulation of Insula-related Brain Networks.02
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Change in Functional Connectivity Strength Measured With Functional Magnetic Resonance Imaging
研究概览
简要总结
The purpose of this study is to investigate the modulatory effects of repetitive transcranial magnetic stimulation (rTMS) on functional connectivity with the insula. Functional connectivity (FC) measures the interaction between brain regions, and recent neuroimaging studies have used FC to investigate how addiction affects FC among pertinent brain regions. rTMS, which can excite cortical neurons, has shown promise as a method to manipulate brain connectivity and could be used therapeutically to treat addiction. However, investigators first need more information on brain FC and how it relates to behavior, in order to guide rTMS target selection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •generally healthy
- •between the ages of 18-55
- •right-handed
排除标准
- •significant health problems (e.g., current and uncontrolled liver, lung, or heart problems) or presence of medical illness likely to alter brain morphology (including history of seizure, history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, and known structural brain lesion)
- •current diagnosis of Axis I psychiatric disorders (e.g., depression, anxiety disorder, schizophrenia)
- •meet DSM-5 criteria for current substance use disorder other than nicotine
- •use of psychoactive medications that would result in a positive urine drug screen
- •Current use of medications known to lower the seizure threshold
- •positive breath alcohol concentration
- •presence of conditions that would make MRI unsafe (e.g., metal implants, pacemakers)
- •among women, a positive urine pregnancy test
- •vision that cannot be corrected to 20/40
研究组 & 干预措施
10 Hz TMS
active TMS will be administered
干预措施: transcranial magnetic stimulation (Device)
1 Hz TMS
active TMS will be administered
干预措施: transcranial magnetic stimulation (Device)
结局指标
主要结局
Change in Functional Connectivity Strength Measured With Functional Magnetic Resonance Imaging
时间窗: baseline and 1 week
Difference in functional connectivity from the TMS target site to the right insula. The primary dependent variable was the resting-state functional connectivity strength between the TMS target site and the right insula.
次要结局
未报告次要终点