Inspiratory effort and assessment of fluid responsiveness in mechanically ventilated patients.

Federico Longhini, MD0 个研究点目标入组 20 人开始时间: 2016年4月22日最近更新: 2020年1月13日

适应症

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•All patients 18 years/old or older undergoing invasive mechanical ventilation in Pressure Support mode (with a positive end-expiratory pressure between 4 and 6 cmH2O and a Pressure Support between 8 and 12 cmH2O), with a clinical need for fluid infusion, i.e. systolic arterial blood pressure < 90 mmHg or 50 mmHg reduction of values in patients with chronic hypertension, oliguria as defined by a diuresis < 0.5 ml/kg/h in the 2 previous hours, need for inotropes (dopamine >5mcg*kg/min or norepinephrine), lactate > 2 mmol/L.

•Patients will be excluded if meeting one or more off the following criteria: 1) cardiac arrhythmia; 2) atrial fibrillation or flutter; 3) patients undergoing any form of renal replacement therapy; 4) valvular defects of moderate to severe grade; 5) history of congestive cardiac failure; 6) previous or presence of pneumothorax or emphysema; 7) patients with Chronic Obstructive Pulmonary Disease (COPD); 8) patients with kyphoscoliosis; 9) use of expiratory muscles and 10) arterial partial pressure to inspired fraction of oxygen (PaO2/FiO2) ratio < 200.

发起方

Federico Longhini, MD