Cognitive Training for Depression
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- change in Hamilton Depression Rating Scale (Ham-D)
研究概览
简要总结
This study is evaluating the effects of two brain training exercises on: memory, cognitive processing and depression symptoms.
详细描述
There is an urgent public health need to develop more effective and well tolerated treatments for patients with major depressive disorder (MDD); cognitive training interventions aiming to modify cognitive and affective processing abnormalities underlying MDD represent a promising new strategy. This research project translates a well established cognitive bias in major depressive disorder (MDD), working memory bias, into a novel intervention target. In a double-blind, randomized, controlled study, MDD participants undergo 4 weeks of cognitive training sessions, with two sessions per week.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary, current Axis I diagnosis of Major Depressive Disorder according to DSM-IV criteria and Ham-D-17 score between 16-27
- •Age 18-55
- •Able to give informed consent
排除标准
- •A history of drug or alcohol abuse or dependence (DSM-IV criteria) within 6 months
- •Visual impairment that would affect the ability to observe the computerized presentation of faces.
- •Motor impairment that would affect the ability to provide a response by quickly pressing a button.
- •Lifetime history of Bipolar spectrum disorders or schizophrenia spectrum disorders.
- •Primary, current Axis I diagnosis other than Major Depressive Disorder
- •Primary, current Axis II personality disorder.
- •Currently attending a cognitive-behavioral psychotherapy regimen
- •Acute suicidal or homicidal risk (evidenced by suicidal or homicidal attempt within 6 months of screening)
- •Pregnancy in women.
- •Subjects must exhibit no or only moderate alcohol use. Subjects with current excessive use of alcohol (> 8 ounces/day for men and > 6 ounces/day for women) are ineligible for participation, as such drug use could confound the results.
结局指标
主要结局
change in Hamilton Depression Rating Scale (Ham-D)
时间窗: baseline and week 4
Change in depression symptom severity at week 4 compared as to baseline
次要结局
- change in Self-referential Information Processing Task(baseline and week 4)
- change in Working Memory(baseline and week 4)