Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair (CoFA-TAAA); a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 58
- 试验地点
- 3
- 主要终点
- Coagulation status
研究概览
简要总结
This study will evaluate the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.
详细描述
Endovascular aneurysm repair of abdominal aorta activates a significant inflammation reaction and has an impact on coagulation. Platelet activation seems to have a major role in this prothrombotic and hypercoagulable state. In complex thoraco-abdominal aortic aneurysm repair the implants are more complexed and the duration of operation longer. The main hypothesis is that all the above have a greater impact on platelet activation and coagulation alterations.
The aim of this study is the evaluation of the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consecutive patients undergoing complex thoraco-abdominal aortic aneurysm repair in University Hospital of Larissa, after informed consent will be included.
排除标准
- •Refuse to participate
- •Prior surgery within 3 months
- •ASA PS > 3
- •Known medical history of thrombophilia or functional platelet dysfunction
结局指标
主要结局
Coagulation status
时间窗: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
Myocardial injury after non cardiac surgery
时间窗: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
Acute kidney injury
时间窗: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
Post-implantation syndrome
时间窗: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
Major cardiovascular events
时间窗: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
Major cardiovascular events, implant failure and death of any cause
时间窗: 30 days, 3, 6, and 12 months postoperatively
Early preoperatively, early and late postoperatively and 1 at one month
次要结局
未报告次要终点
研究者
Elena Arnaoutoglou
Professor of Anaesthesiology
University of Thessaly