跳至主要内容
临床试验/CTRI/2024/01/061636
CTRI/2024/01/061636尚未招募不适用

Histologic Analysis of Female Urethral Strictures Following Dorsal On lay Buccal Mucosal Graft Urethroplasty

Department of Urology1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年6月2日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
30
试验地点
1
主要终点
a)Evaluation for epithelial hyperplasia and cell type

研究概览

简要总结

There is no literaturewith regard to the histopathology of female urethral stricture diseasecurrently. In a recent study by RamPathak et al of 9 patients who underwent urethroplasty, 67 % of the patients had stratified squamousepithelium overlying fibrosis, while 29% showed acute injury with prominentsquamous papillary hyperplasia. While many studies have looked into the pathophysiologyof Urethral Stricture Disease in males and suggested that chronic inflammationand Lichen’s Sclerosis are the most common findings, there is a huge paucity ofdata with regard to females. Here, we look to present the pathologicanalysis of female urethral stricture disease.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 99.00 Year(s)(—)
性别
Female

入选标准

  • 1.Females aged 18 years or above with urethral stricture disease confirmed by uroflowmetry and cystoscopy.
  • 2.Females who undergo a dorsal onlay buccal mucosal graft urethroplasty.
  • 3.Written informed consent.

排除标准

  • 1.Patients who have undergone surgery for urethral stricture disease previously 2.Patients in whom ventral BMGU is performed.
  • 3.Patients with STDs 4.Patients with genitourinary anomalies 5.Patients who have had surgery for hypertrophy of the bladder neck 6.Patients who have had radiation to the pelvis 7.Patients with bladder malignancies.

结局指标

主要结局

a)Evaluation for epithelial hyperplasia and cell type

时间窗: 10 days

次要结局

  • a)To evaluate the presence of mucosal oedema(b)To evaluate the degree of fibroblast/inflammatory cell infiltrate)

研究者

申办方类型
Research institution and hospital

研究点 (1)

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