Investigating the Effects of Increased Water Consumption on Markers of Gut Health, Microbiota, and Executive Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Fecal microbiota relative abundance
研究概览
简要总结
The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool. Therefore the specific aims are 1) to quantify intervention effects on fecal microbiota relative abundance and plasma lipopolysaccharide binding protein, 2) observe the effects of the intervention on bowel frequency and signs/symptoms of gastrointestinal stress, and 3) to investigate relations between executive function and hydration status.
详细描述
A single arm 3-week hydration intervention will be employed where participants increase their water consumption to 2 (F) or 2.5(M) liters per day which is approximately 70% of the AI for daily water consumption. Pre-test and follow-up measures of fecal microbiota, urinary hydration status, cognitive function, circulating markers, and dietary intake will be assessed at baseline and at 3-week follow up via laboratory visits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •19-50 years of age
- •18.5-34.49 kg/m2
- •24-hour UOsm above 500 mOsm/kg
- •No antibiotic use over the past 3 months
- •Absence of metabolic diseases and use of diuretics
- •Agree to maintain typical diet intake (e.g., dietary fiber) patterns during intervention
- •Avoid consuming prebiotic and probiotic supplements during study participation
- •Not pregnant
- •Agree to follow the study protocol
排除标准
- •<19 or >50 years of age
- •<18.5 or >34.49 kg/m2
- •24-hour UOsm <500 mOsm/kg
- •Antibiotic use over the past 3 months
- •Metabolic diseases and use of diuretics
- •Not agree to maintain typical diet intake (e.g., dietary fiber) patterns for the duration of the
- •intervention
- •Not agree with avoiding consuming prebiotic and probiotic supplements during study participation
- •Not agree to follow study protocol
研究组 & 干预措施
Water Intake
3-week intervention period during which articipants will be asked to increase their daily plain water consumption to at least 2.5 L/d of water for males and 2L/d for females.
干预措施: Water Intake (Dietary Supplement)
结局指标
主要结局
Fecal microbiota relative abundance
时间窗: 3 weeks (baseline vs. follow-up)
changes in the relative abundance of fecal microbiota
Plasma lipopolysaccharide (LPS)
时间窗: 3 weeks (baseline vs. follow-up)
changes in circulating LPS
次要结局
- Attentional accuracy(3 weeks (baseline vs. follow-up))
- Attentional Reaction Time(3 weeks (baseline vs. follow-up))
- 24hr Urine Osmolality(3 weeks (baseline vs. follow-up))
- Copeptin(3 weeks (baseline vs. follow-up))
- Attentional processing speed(3 weeks (baseline vs. follow-up))
- 24hr Urine Specific Gravity(3 weeks (baseline vs. follow-up))
研究者
Naiman Khan
Associate Professor
University of Illinois at Urbana-Champaign