Evaluating the effect of topical application of gel containing high concentrations of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) with stannous fluoride on white spot lesions in enamel in situ in healthy adults

niversity of Melbourne0 个研究点目标入组 4 人开始时间: 2022年9月20日最近更新: 2022年9月26日

适应症

试验速览

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•Inclusion Criteria
•Age range: 18 to 75 years.
•Gender: Males and females.
•Good general health.
•At least 22 natural teeth
•A gum- stimulated whole salivary flow rate at least 1.0 ml/minute and unstimulated whole salivary flow rate at least 0.2 ml/minute.
•Available for both treatment periods.

•The exclusion criteria include:
•1) History of adverse or allergic reactions to milk proteins (such as casein), tin or tin-containing products, or any other ingredients in the
•2) Orthodontic appliances or removable dentures;
•3) Veneers, or more than one incisor with an artificial crown;
•4) Oral diseases including advanced periodontal disease;
•5) Chronic disease such as diabetes or use of medications that cause gum swelling;
•6) Untreated decay;
•7) Treatment with antibiotics or anti-inflammatory medicines in the month prior to starting the study;
•8) Use of drugs that may interact with the toothpaste slurries or which may affect salivary flow rate;
•9) History of health conditions requiring antibiotic coverage prior to dental treatment;
•10) Pregnancy/lactation;
•11) Serious infectious disease;
•12) Any other medical or dental condition deemed to put the health and wellbeing of you or the research team at risk if you participated in

发起方

niversity of Melbourne