Home-Reported Outcomes in People With Cystic Fibrosis (CF) Taking Highly Effective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulator Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 860
- 试验地点
- 1
- 主要终点
- Change in FEV1 percent predicted
研究概览
简要总结
This is an observational cohort study, using data from Folia Health and the Cystic Fibrosis Foundation Patient Registry (CFFPR). Individuals taking elexacaftor/tezacaftor/ivacaftor (ETI) may be enrolled through the Folia application. During the 12-month study period, participants will be asked to track their routine treatment and medication usage, daily symptoms, and monthly review with validated patient-reported outcome (PRO) questionnaires. Participants will also be asked to self-report instances of changes to their treatment plan, and pulmonary exacerbations. There are no study-associated site visits.
详细描述
This study will be a prospective, observational cohort study to investigate the changes in lung function among individuals who have made treatment changes after initiating treatment with elexacaftor/tezacaftor/ivacaftor (ETI). Data will be collected from Folia Health, and the Cystic Fibrosis Foundation Patient Registry (CFFPR) for participants who are registered. Participation in the study will occur through the Folia application where study participants will be directed to a specific HERO-2 study dashboard. Individuals (n=860) taking ETI may be enrolled at participating sites, through social media recruitment or from existing users of Folia Health. During the 12-month study period, participants will be asked to track their routine treatment and medication usage, daily symptoms, and monthly review with validated CF patient-reported outcome (PRO) questionnaires. Participants will also be asked to self-report instances of changes to their treatment plan, and pulmonary exacerbations. Data collected within Folia will be linked to the CFFPR for individual outcomes with regards to clinical data including anthropometric measures, lung function, complications, and IV-treated pulmonary exacerbations. This study will not provide or recommend any treatment recommendations. All direction for medication usage is solely at the discretion of the patient's physician in accordance with their usual practice.
The primary objective for the study will be to evaluate changes in lung function as measured by forced expiratory volume over one second (FEV1) percent predicted in individuals who report making at least one change to chronic daily respiratory therapies upon study entry and during the 12 month follow up compared to those who do not make changes to chronic daily therapies. Secondary endpoints will include a measurement of the proportion of individuals making changes to chronic daily therapy, the need to resume chronic daily therapy, health-related quality of life, symptom severity and symptom frequency, and pulmonary exacerbations requiring IV antibiotics.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Written informed consent (and assent when applicable) obtained from subject or subject's legal guardian.
- •Is willing and able to adhere to protocol requirements.
- •≥ 12 years of age at enrollment.
- •Diagnosed with CF.
- •Prescribed ETI for an on-label indication.
- •Participant has access to a mobile phone or tablet (iPhone or Android platform) or computer.
- •Participant has access to an internet connection.
排除标准
- •Participant is enrolled in the randomized portion of the SIMPLIFY study (NCT04378153).
- •Participant does not have access to the necessary technology.
- •Participant is a recipient of a solid organ transplant (i.e. lung, liver, pancreas, kidney).
- •Participant cannot communicate in English.
结局指标
主要结局
Change in FEV1 percent predicted
时间窗: 12 months
The primary outcome measure of this study is change in FEV1 percent predicted at 12 months.
次要结局
未报告次要终点
研究者
Cynthia Brown
Professor of Clinical Medicine
Indiana University