Effects of the Longevity Diet and the Fasting-mimicking Diet on Body Composition, Risk Factors for Age-related Diseases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 365
- 试验地点
- 1
- 主要终点
- Fat mass in %
研究概览
简要总结
This retrospective clinical study examines the impact of the longevity diet and fasting-mimicking diet (FMD), either alone or combined, on body composition and health indicators. Focused on subjects from the Valter Longo Foundation (2019-2024), the study aims to evaluate their effects on body fat percentage, lean mass, muscle function, and lipid profiles.
The longevity diet, rooted in centenarian dietary traditions, emphasizes isocaloric meals with a balance of complex carbohydrates, unsaturated fats, and plant-based proteins. FMD involves a 5-day highly hypocaloric vegan diet to simulate fasting benefits. Hypothesizing that a return to a modified Mediterranean diet or incorporating FMD could improve overall health, the study spans diverse cohorts based on intervention type, duration, obesity level, and physio-pathological status.
Data, collected from electronic medical records, will undergo statistical analyses to compare pre- and post-intervention measurements, exploring outcomes across subgroups. Ethical considerations, including de-identified data and informed consent, ensure compliance with clinical research regulations.
In conclusion, this study provides valuable insights into the potential health and longevity benefits of the longevity diet and FMD, with implications for public wellness.
详细描述
- Introduction Aging is often accompanied by numerous chronic degenerative conditions that compromise the quality of life and lead to dependency. However, a favorable interaction between genetic and environmental factors could lead to a significantly higher life expectancy, free from conditions that significantly compromise both the quality and duration of life, highlighting that increased longevity is not necessarily accompanied by one or more pathological conditions.
It is widely accepted that the quality and quantity of nutrition are essential factors in maintaining health and preventing diseases. Making healthy and conscious dietary choices can indeed alter the course of life in terms of both duration and health.
Numerous epidemiological studies have demonstrated the critical role of a proper dietary regimen in the risk of developing age-related diseases. Furthermore, recent studies have highlighted how short periods of extreme calorie reduction with adequate nutrient intake (5 days, fasting-mimicking diet, FMD) can impact metabolism, producing numerous beneficial effects in both healthy individuals and those with chronic degenerative conditions such as cancer, cardiovascular diseases, diabetes, and autoimmune diseases.
Theories about senescence usually focus on the aging process and not on the ability of organisms to stay young. The longevity diet proposed in this study is intended to be effective in achieving the goal of extending youth for as long as possible, optimizing protection, regeneration, and rejuvenation while minimizing diseases. It is based on five pillars that support the scientific evidence of the program: basic research, epidemiology, clinical studies, centenarian studies, and complex systems studies.
Essentially, the longevity diet incorporates the dietary tradition of healthy centenarians, characterized by simplicity and products typical of their region of origin.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy patients and/or those with diseases, excluding neoplastic and neurodegenerative pathologies;
- •Age >/= 18 years;
- •Body mass index >/= 18.5 kg/m2;
- •At least two visits, both characterized by bioimpedance and anthropometric analysis;
- •At least 3 months between the first and last bioimpedance and anthropometric analysis;
- •Signature of informed consent and privacy for the conducted visits.
排除标准
- •Age < 18 years;
- •Lack of informed consent or privacy;
- •Women who are pregnant or breastfeeding;
- •Patients affected by oncological and/or neurodegenerative pathologies.
结局指标
主要结局
Fat mass in %
时间窗: Comparison of Fat mass in % at baseline and after a period between 3 months (minimum) and 2 years (maximum)
The percentage of the Fat Mass in measured through a Bioimpedance Analysis (BIA) or a caliper
次要结局
- Phase Angle(Comparison of Phase Angle at baseline and after a period between 3 months (minimum) and 2 years (maximum))
- Free Fat Mass in percent(Comparison of Free Fat Mass in percent at baseline and after a period between 3 months (minimum) and 2 years (maximum))
- Waist Circumference(Comparison of Waist Circumference at baseline and after a period between 3 months (minimum) and 2 years (maximum))
- Hips Circumference(Comparison of Hips Circumference at baseline and after a period between 3 months (minimum) and 2 years (maximum))
- Total Cholesterol(Comparison of Total Cholesterol maximum 6 months before the first consultation and maximum 6 months after the last consultation)