A Comparative study of efficacy and safety of combination treatment with oral minocycline and narrowband UV-B phototherapy versus narrowband UV-B alone in generalized vitiligo

Srinakharinwirot University0 个研究点目标入组 44 人开始时间: 2021年3月11日最近更新: 2024年8月19日

适应症

试验速览

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•Subject (man or woman) is older than 18 years old
•Subject with generalized vitiligo with a body surface area involved >10%
•Subject is able to recieve phototherapy treatment twice a week for 12 weeks
•subject is willing to participate in research project with sign the inform consent before attend the study and can be responsible to treatment along total course.

•subject has recieved in the 3 month prior to enrolment the following therapies; phototherapy, any immunomodulator, systemic corticosteroids and any antioxidants.
•subject has recieved the topical treatment (topical corticosteroids, topical vitaminD) within 2 weeks of enrolment.
•subject has a history of radiotherapy, chemotherapy or immunosuppressive therapy
•subject has a history of skin cancer,photosensitivity or photomediatied disorders and claustrophobia
•subject has been diagnosed as renal failure or liver disease.
•subject has an abnormal liver enzyme test (AST,ALT) ,eGFR<60mg/ml and ANA titer more than 1:160
•sudject has a history of allergy to tetracyclines.
•subject is pregnant(as determined by LMP)or subject is breastfeeding.

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