Intracranial Pressure After Decompressive Craniectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 主要终点
- Intracranial pressure variations
研究概览
简要总结
Observational study to investigate the natural course of intracranial pressure (ICP) after decompressive craniectomy (DC) using long-term telemetric ICP monitoring. Patients will have continuous ICP measurement performed during the admission to the neuro-intensive care unit (NICU) and after discharge weekly measurements sessions will be performed before and after cranioplasty.
详细描述
Several studies have investigated and documented the effect of DC in lowering ICP in intracranial hypertension following acute brain injuries, e.g. severe traumatic brain injury. But the natural course of ICP in these patients after the acute phase in the NICU has never been investigated. Clinical experience suggests that a DC affects cerebrospinal fluid circulation and ICP, e.g. causing hydrocephalus or subdural hygromas.
The aim of this observational study is to document the natural course of ICP following DC and to investigate the effect of cranioplasty on ICP. This is done by implantation of a telemetric ICP sensor and weekly follow-up monitoring sessions after discharge from the NICU until 1 month after cranioplasty. The monitoring sessions will include standardized body positions to investigate postural ICP changes before and after cranioplasty. The project will also provide experience with telemetric ICP monitoring during the acute phase in a NICU setting.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 years
- •scheduled for a decompressive hemicraniectomy for elevated ICP or signs of intracranial herniation
排除标准
- •skin damage in the frontal area where the telemetric ICP sensor is implanted
- •lack of informed consent from next-of-kin or the patient's general practitioner
结局指标
主要结局
Intracranial pressure variations
时间窗: Weekly monitoring sessions from discharge from the neuro-intensive care unit to 1 month after cranioplasty
ICP is measured in standardized body positions to investigate postural changes after decompressive craniectomy and following cranioplasty
次要结局
未报告次要终点
研究者
Alexander Lilja-Cyron
MD, PhD fellow
Rigshospitalet, Denmark
