Incidence of Acute Renal Failure Associated With Iodinated Contrast Agents in Pediatrics. Study CANOPY. Prospective Multicenter Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 4
- 试验地点
- 2
- 主要终点
- Diuresis
研究概览
简要总结
Iodinated contrast media are now frequently used in diagnostic imaging exams, including pediatrics.
In adults, the acute renal failure (ARF) associated with contrast agents (CA-AKI) occur in 3-33% of exposed patients, especially as the patient is fragile, has comorbidities or pre-existing renal aggression .
In children, the prevalence of this little known disease is probably underestimated.
The investigators intend to conduct a prospective epidemiological study, to estimate the impact of the acute renale failure to iodinated contrast agents in pediatrics.
详细描述
Patients will be included those of pediatric emergencies, Hospitalization Unit of Short Duration pediatric, pediatric intensive care and pediatric resuscitation. The acute renale failure will be estimated on the basis of criteria KDIGO (score of kidney disease) group in 2012 to 48 hours a computed tomography (CT) scan with injection of contrast media, based on a change in creatinine clearance of the estimated according to the formula Schwartz revised in 2009 and / or diuresis.
Patient characteristics will be identified in order to establish risk factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients under 16 years admitted to a participating service
- •Patient receiving an injected CT scan
排除标准
- •Prior Inclusion in the study during an earlier review.
- •Opposition of parents.
- •Chronic renal failure or end-stage requiring renal replacement in the long term.
结局指标
主要结局
Diuresis
时间窗: change from baseline diuresis at 7 days
data gathered in the medical file
Creatinine
时间窗: change from baseline creatinine at 7 days
data gathered in the medical file
次要结局
- Renal replacement(at 7 days)
- Death(at 7 days)
- Readmission(at 7 days)
- Hospitalization in intensive care(at 7 days)