TCTR20171004004已完成4 期
Efficacy and Safety of Enteral Erythromycin Estolate in Combination with Intravenous Metoclopramide versus Intravenous Metoclopramide Monotherapy in Mechanically Ventilated Patients with Enteral Feeding Intolerance: A Randomized Pilot Study
Siam University0 个研究点目标入组 30 人开始时间: 2017年10月4日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 0 N/A (No limit)（—）
- 性别
- All
入选标准
- •Mechanically ventilated patients who had feeding intolerance, defined as GRV greater than or equal to 250 mL during receive either continuous or intermittent enteral feeding or GRV greater than or equal to 150 mL concomitant with vomiting, regurgitation or abdominal distension.
排除标准
- •The patients who
- •1. received any prokinetics drugs within the past 24 hours
- •2. have a history of allergic to metoclopramide and/or macrolide antibiotics
- •3. required pharmacological treatment for seizure
- •4. have hemodynamically unstable or any cardiac arrhythmia or prolonged QTc > 480 msec. on a 12-lead ECG
- •5. was diagnosed with acute CNS infection
- •6. was diagnosed with acute severe brain injury from any causes
- •7. have hyperbilirubinemia
- •8. currently received carbamazepine, digoxin, warfarin, haloperidol or perphenazine
- •9. have undergone small bowel or large bowel surgery within 6 weeks before study
- •10. have a history of esophagectomy or partial/total gastrectomy at any time before study
- •11. was diagnosed with myasthenia gravis or pheochromocytoma
- •12. was suspected or confirmed bowel obstruction or perforation, 13. were expected to be extubated within 48 hours
- •14. Declined to participate
研究者
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