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临床试验/CTRI/2024/03/063446
CTRI/2024/03/063446招募中不适用

Ability of plethysmographic perfusion index to detect fluid responsiveness during the immediate post-operative period in cardiothoracic surgery patients – a prospective observational study

Sree Chitra Thirunal Institute Medical Sciences and Technology1 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2024年3月10日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
400
试验地点
1
主要终点
To study the reliability of change in plethysmographic perfusion index for predicting fluid responsiveness immediately following admission in adult postoperative ICU after cardiothoracic surgery till peripheral temperature is increased

研究概览

简要总结

Hemodynamic management post-cardiac surgery is crucial for optimal patient outcomes. Hemodynamic instability is common, exacerbated by hypovolemia and vasodilation. The goal is to maintain perfusion and oxygen delivery, targeting variables like heart rate, mean arterial pressure, and central venous pressure. Fluid resuscitation is vital for early instability, addressing blood loss, vascular capacitance, fluid losses, and increased preload requirements. Assessing preload dynamics is challenging, with static pressures poorly predicting fluid responsiveness. Dynamic approaches like pulse pressure and stroke volume variation have limitations.

Plethysmographic perfusion index (PI) offers a non-invasive method to assess fluid responsiveness. PI, derived from pulsatile and non-pulsatile light absorption, reflects arterial volume changes during the cardiac cycle. PI varies with changes in vascular tone, making it a potential indicator of fluid responsiveness. Studies show correlations with vascular tone changes induced by anesthesia and vasopressors.

Our study aims to validate PI for detecting fluid responsiveness in postoperative cardiac patients during warming until peripheral temperature reaches 30 C. We’ll also explore the correlation between PI changes and fluid requirements. If proven reliable, PI could revolutionize non-invasive fluid assessment, aiding cardiac care providers in optimal postoperative fluid resuscitation.

Hypothesis:

There is correlation between change in plethysmographic perfusion index and postoperative fluid responsiveness in immediate postoperative period in patients who underwent cardiothoracic surgery.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • All postoperative adult patients scheduled for elective cardiothoracic surgery.

排除标准

  • Refusal to participate Emergency surgeries Redo surgery Severe LV dysfunction Preoperative inotropic requirement Arrythmias Vasoactive-inotrope score of more than 15 Massive blood loss Patients on renal replacement therapy.

结局指标

主要结局

To study the reliability of change in plethysmographic perfusion index for predicting fluid responsiveness immediately following admission in adult postoperative ICU after cardiothoracic surgery till peripheral temperature is increased

时间窗: 0 min, 15 min, 30 min, 60 min, 120 min

次要结局

  • To compare change in plethysmographic perfusion index with parameters involving change in VTI, CVP, IVC diameter for detecting fluid responsiveness.(In fluid responders, whether any change in PPI can predict the fluid requirement)

研究者

发起方
Sree Chitra Thirunal Institute Medical Sciences and Technology
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr Abinaya Prakashbabu U

Sree Chitra Thirunal Institute of Medical Sciences and Technology

研究点 (1)

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