Single Arm Clinical Study To Evaluate The Efficacy Of Madhuyashtydi Syrup In The Management Of Pittaj Mutrakruchhra With Special Reference To UTI In Children

Urinary tract infections (UTIs) are among the most common bacterial infections in the pediatric population, contributing significantly to morbidity. They present with symptoms such as dysuria, increased frequency of micturition, lower abdominal pain, and fever, and may lead to recurrent infections and renal complications if inadequately treated. The rising incidence of antimicrobial resistance and recurrence has necessitated the exploration of alternative and adjunct therapeutic options.

In Ayurvedic literature, the clinical features of UTI can be correlated with Pittaj Mutrakruchhra, characterized by symptoms like daha (burning micturition), mutradaha, peeta mutrata, and alpa-alpa mutrapravritti. Madhuyashtyadi Syrup, a classical Ayurvedic formulation, possesses properties such as sheeta virya, pitta-shamaka, mutrala, and vrana shodhana, which may help in alleviating inflammation, reducing urinary discomfort, and promoting urinary tract health.

Purpose of the Trial

The present single-arm clinical study is designed to evaluate the efficacy of Madhuyashtyadi Syrup in the management of Pittaj Mutrakruchhra with special reference to urinary tract infections in children. The study aims to assess its effect on clinical symptoms (such as dysuria, frequency, and burning micturition) and relevant laboratory parameters (e.g., urine routine and microscopy). Additionally, the study seeks to determine the safety and therapeutic potential of the formulation as an alternative or supportive treatment in pediatric UTIs.