Early detection and psychological intervention for individuals at high risk of psychosis 2

niversity of Manchester (UK)0 个研究点目标入组 320 人开始时间: 2008年8月29日最近更新: 2015年1月13日

试验速览

暂无简介。

•Trial entry criteria will be assessed using the Comprehensive Assessment of At-Risk Mental States (CAARMS). Patents must satisfy one of the following to be eligible for inclusion into this study:
•1. Brief limited intermittent psychotic symptoms (BLIPS) defined as a score of 6 on any positive item, with symptoms lasting less than one week and resolving without antipsychotic medication
•2. Attenuated symptoms (AS), defined as the presence of positive symptoms that score 3-5 and have begun in the last year and which occur at least once per week in the last month
•3. State-plus-trait group (SPT), operationally defined by the presence of an at-risk mental state (recent deterioration in function of 30 points or more on the Global Assessment of Functioning) plus either a family history indicated by a first degree relative with a history of any psychotic disorder or a diagnosis of schizotypal personality disorder in the participant
•In addition, the patient must fulfil both of the following:
•4. Age 14-35
•5. Seeking help for symptoms (the latter criterion is necessary to ensure that the provision of treatment to the participants is ethical)

•1. Current or previous receipt of antipsychotic medication for more than two days
•2. Moderate to severe learning disability
•3. Organic impairment
•4. Non-English speaking (since this would prevent the use of standardised assessment instruments)

发起方

niversity of Manchester (UK)