跳至主要内容
临床试验/CTRI/2025/02/081106
CTRI/2025/02/081106尚未招募不适用

To investigate the clinical diagnostic potential of dysregulated microRNAs as early biomarkers in breast cancer patients

PRAMOD KUMAR AVTI1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2025年2月28日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
15
试验地点
1
主要终点
Post surgical breast tumor tissue/blood will be collected for miRNAs expression, tumor suppressor genes, DNA repair genes and breast cancer receptor marker expression.

研究概览

简要总结

The dysregulation of epidermal growth factor receptors and hormonal receptors in breast cancer can be attributed to various factors, including the influence

of non-coding RNAs, particularly microRNAs.

These small RNA molecules play a pivotal role in post-

transcriptional gene regulation and have been implicated

as key players in breast cancer pathogenesis. In breast cancer, aberrant expression of miRNAs has been

observed, with many miRNAs found to be upregulated. These dysregulated miRNAs exert their influence by

modulating DNA repair activity and tumor suppressor

functions, thereby promoting cancer initiation and

progression and contributes to the molecular complexity

of breast cancer.

This study aims to delve into the intricate role of miRNAs

in the progression of breast cancer, elucidating their

influence on molecular markers, tumor suppressor genes, and DNA repair activity within breast cancer patient

samples. By analyzing a panel of miRNAs in these

patients, we seek to uncover potential biomarkers crucial

for diagnosing breast cancer early and distinguishing

between different subsets of the disease within a single

comprehensive study.

研究设计

研究类型
Observational

入排标准

年龄范围
20.00 Year(s) 至 80.00 Year(s)(—)
性别
Female

入选标准

  • Female breast cancer patients.
  • Breast cancer patient age between 20-80 years.
  • Patient diagnosed through mammographic techniques.
  • All stages of diseases.
  • Surgery or mastectomy patients will be included.
  • With or without treatment patients will be included in this study.

排除标准

  • 未提供

结局指标

主要结局

Post surgical breast tumor tissue/blood will be collected for miRNAs expression, tumor suppressor genes, DNA repair genes and breast cancer receptor marker expression.

时间窗: The samples will be processed and analyzed at 12 months

次要结局

未报告次要终点

研究者

发起方
PRAMOD KUMAR AVTI
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

PRAMOD KUMAR AVTI

POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH

研究点 (1)

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