TIBOLA : Multicenter Descriptive Study in Eastern France
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Number of cases of TIBOLA
研究概览
简要总结
TIBOLA (TIck-BOrne LymphAdenopathy) is a tick-borne disease. The pathogen is most often rickettsia (R. slovaca or R. raoultii), but other strict intracellular bacteria have been described (Francisella tularensis, Coxiella burnetii, Bartonella hensenlae).
Transmitted by ticks (Dermacentor), it is characterized by an inoculation eschar at the tick bite site, accompanied by painful loco-regional lymphadenopathy. It is most often a benign pathology, which can nevertheless leave sequellar alopecia or persistent asthenia.
In spring 2021, an impression of increased cases was reported by clinicians in Eastern France. The study aims to clarify the clinical-biological presentation and the evolution of the number of cases of TIBOLA in this region between 2016 and 2021.
At the same time, entomologists have noted an upsurge in this tick in certain biotopes in recent years.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Person, minor or major,
- •having been diagnosed with TIBOLA
- •between January 1, 2016 and December 31, 2021
- •at the University Hospital of Nancy or Strasbourg in the departments of infectious and tropical diseases, dermatology, microbiology and pediatrics.
排除标准
- 未提供
结局指标
主要结局
Number of cases of TIBOLA
时间窗: baseline
次要结局
- Frequency of the various symptoms and clinical signs of the disease(baseline)
- Characteristics of tick bites(baseline)
- Entomological analysis(evolution between 2016 and 2021)
- Epidemiological and demographic characteristics(baseline)
- Biological results(baseline)
- Treatment(baseline)
研究者
Elisabeth BAUX
Principal Investigator
Central Hospital, Nancy, France