ACTRN12610000378022已完成2 期
The effect of oral metformin on spirometry, exercise capacity and quality of life in adults with chronic obstructive pulmonary disease (COPD) and either diet-controlled type 2 diabetes mellitus or impaired glucose tolerance.
Dr Paul Sexton0 个研究点目标入组 40 人开始时间: 2010年5月11日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 45 Years 至 o limit（—）
- 性别
- All
入选标准
- •*Obese (body mass index > 30)
- •*Central pattern of obesity (elevated waist circumference)
- •*Impaired glucose tolerance or diet-controlled type 2 diabetes mellitus (previous diagnosis, or evidence of blood tests meeting American Diabetes Association 2010 criteria)
- •*Post-bronchodilator spirometry that is consistent with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 2+ COPD
- •*Symptomatic: Medical Research Council dyspnoea score of 2 or higher
排除标准
- •1.Currently taking oral hypoglycaemic agent or insulin
- •2.Active respiratory disease other than obstructive airways disease
- •3.Exacerbation of airways disease requiring change in treatment within the preceding 6 weeks
- •4.Participation in pulmonary rehabilitation programme within the past 6 weeks
- •5.Currently prescribed long term oral corticosteroids
- •6.Renal impairment (estimated glomerular filtration rate < 45 mL/min)
- •7.Cirrhosis, impaired synthetic liver function, or liver failure
- •8.Chronic respiratory failure
- •9.Congestive heart failure
- •10.Current or recent habitual heavy alcohol intake
- •11.Current use of antiretroviral medication
- •12.Pregnancy
- •13.History of lactic acidosis
- •14.Allergy to metformin
- •15.Unable to comply with the study procedures or protocol
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