NCT00837057Unknown4 期
A Randomized Controlled Multi-Center Trial of the Early Application of CRRT in Patients With Severe Sepsis or Septic Shock
适应症
试验速览
- 阶段
- 4 期
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Death from all causes at 28 days after randomisation
研究概览
简要总结
Severe sepsis or septic shock with acute kidney injury shows high mortality in intensive care unit. A few studies have shown CRRT relating the clinical improvement seems to be related to the early initiation of therapy. But there is no consensus for proper time of CRRT may improve the prognosis.
The study is a prospective randomized one center trial comparing two treatments in patients suffering from septic shock complicated with acute renal failure admitted to ICU, treated either early by CRRT (35 ml/kg/h) or by conventional RRT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Septic shock (Bone criteria) for less than 14D
- •RIFLE criteria : Injury or Failure or nearly anuria more than 2hr
- •Age over 18 years
- •Written informed consent by next of kin.
排除标准
- •Cirrhosis child class C
- •CRF or ESRD
- •Too high APACHE II & SOFA score at admission
- •Age over 80 years
- •Life expectancy less than 3 months (metastatic cancer - hepatoma, lung ca.)
结局指标
主要结局
Death from all causes at 28 days after randomisation
时间窗: 28 day
次要结局
- Death within the in the intensive care unit. Death within 90 days of randomisation. Death prior to hospital discharge. Length of ICU stay. The need for and duration of other organ support(90 day)
研究者
研究点 (1)
Loading locations...
相似试验
终止
3 期
Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic ShockVasopressor ResistanceSeptic ShockNCT03953677Centre Hospitalier Universitaire Dijon32
已完成
3 期
Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe SepsisSevere SepsisSeptic ShockNCT00832039Kompetenznetz Sepsis1,089
已完成
不适用
Thermodilution - Controlled Management of Volume Therapy in Septic ShockVolume StatusSeptic ShockNCT01263977Claudia Spies60
终止
2 期
Furosemide in Early Acute Kidney InjuryAcute Renal FailureNCT00978354University of Alberta72
招募中
不适用
Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )Critical IllnessAcute Kidney InjuryNCT06021288Universität Münster165