The effect of routine pantoprazole administration when compared to placebo on gastrointestinal bleeding, ventilator-associated pneumonia and Clostridium difficile infection in enterally-fed mechanically ventilated critically ill patients: A prospective randomised study

Dr Adam Deane0 个研究点目标入组 500 人开始时间: 2013年7月22日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•Consecutive patients admitted to the ICU at the RAH who are anticipated to remain mechanically ventilated for > 24 hours AND receive enteral nutrition within 48 hours of admission

•1. Current (prior to hospital admission) use of proton pump inhibitor or histamine-2 receptor blocker drugs
•2. Pregnancy
•3. Patients admitted with suspected or proven gastrointestinal bleeding
•4. Patients with a history of proven peptic ulcer disease
•5. Patients receiving > 400 mg/day of hydrocortisone (or equivalent of prednisolone (100mg) or dexamethasone (15mg))
•6. History of surgery on the oesophagus, stomach or duodenum during the current hospital admission
•7. Patients where the treating consultant intensive care physician believes that stress ulcer prophylaxis is either clearly indicated or contraindicated
•8. Patients who are Jehovah’s Witnesses
•9. Patients who do not receive their first dose of study medication within 36 hours of initiation of mechanical ventilation (this criterion is required to avoid contamination of cohorts as if stress ulcer prophylaxis is beneficial it is likely to be of benefit when commenced as early as possible and patients who have been ventilated at another hospital for > 24 hours may have received stress ulcer prophylaxis).
•10. Patients admitted for palliative care.
•11. Patients readmitted to the Intensive Care Unit

发起方

Dr Adam Deane