Vegan Diets: the Short-term Effects on Daily Muscle Protein Synthesis Rates as Compared to Omnivorous Diets in Older Adults Assessed by D2O.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Muscle Protein Synthesis (MPS)
研究概览
简要总结
Consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. However, the consequences of such a transition on muscle mass still remains to be explored. This is of particular importance in the older population, where sarcopenia is highly prevalent. The aim of this randomized controlled cross-over study is to investigate the short-term effect of a 10-day controlled vegan diet on daily muscle fractional synthesis rates in comparison to a 10-day controlled omnivorous diet in 35 community-dwelling older adults.
Participants will follow a fully controlled vegan diet, directly followed by a fully controlled omnivorous diet for 10 days, or vice versa. Researchers will compare the effect of the vegan diet to the effect of the omnivorous diet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 79 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 65-79 years old;
- •Community-dwelling;
- •BMI 20-35 kg/m^2.
排除标准
- •Following a vegetarian or vegan diet during the six months prior to the study;
- •Following a diet that affects protein intake during the six months prior to the study;
- •Participating in a structured exercise training program in the past three months;
- •5% or more body weight loss during three months before the start of the study;
- •Being diagnosed with one of the following: diabetes; renal disease; neurological or neuromuscular disorders; serious cardiovascular diseases; cancer; chronic obstructive lung disease (COPD);
- •Chronic use of medication that affects muscle function, e.g. corticosteroids, metformin, insulin;
- •The use of the following medicines: acenocoumarol (sintrom); phenprocoumon (marcoumar); dabigatran (pradaxa); apixaban (eliquis); rivaroxaban (xarelto); clopidogrel (plavix); combination of acetylsalicylic acid or carbasalate calcium (ascal) with dipyridamole.
- •Allergic or intolerant to any product included in the diets;
- •Not willing to stop nutritional supplements, with the exception of supplements on medical advice, and vitamin D;
- •Not willing or afraid to give blood or undergo a muscle biopsy during the study;
- •Unwilling to eat a vegan and an omnivorous diet for ten days each;
- •Currently a research participant in another trial or participated in a clinical trial during three months before the start of the measurement period;
- •Not being able to understand Dutch;
- •Not having a general physician.
研究组 & 干预措施
VO group
Vegan diet followed by Omnivorous diet
干预措施: Vegan diet (intervention) (Other)
VO group
Vegan diet followed by Omnivorous diet
干预措施: Omnivorous diet (control) (Other)
OV group
Omnivorous diet followed by Vegan diet
干预措施: Vegan diet (intervention) (Other)
OV group
Omnivorous diet followed by Vegan diet
干预措施: Omnivorous diet (control) (Other)
结局指标
主要结局
Muscle Protein Synthesis (MPS)
时间窗: 10 days
MPS, expressed as daily fractional synthesis rates (FSR, %/day), will be assessed using a deuterium oxide protocol. Daily FSR will be calculated using the 2\^H-alanine enrichment in plasma and the mixed muscle-bound 2\^H-alanine enrichment.
次要结局
- Change in fasting plasma glucose(Change after 10 days of following each diet)
- Change in fasting plasma insulin(Change after 10 days of following each diet)
- Change in blood pressure(Change after 10 days of following each diet)
- Appetite(Measured daily for 10 days during each diet)
- Change in fasting plasma lipid profile(Change after 10 days of following each diet)
研究者
Lisette de Groot
Prof. Dr. Ir. L.C.P.G.M. (Lisette) de Groot
Wageningen University