NCT03094494已完成不适用
Double Carbapenem as Rescue Strategy for the Treatment of Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections: A Two-Center Matched Case-Control Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 144
- 主要终点
- 28-day mortality
研究概览
简要总结
An observational two-center case-control study exploring the clinical impact of double-carbapenem use in a population of critically il patients with severe carbapenem-resistant Klebsiella pneumoniae infection
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 18 years;
- •ICU admission between November 2012 and December 2015;
- •documented CR-Kp invasive infection;
- •targeted antibiotic therapy lasting ≥ 72 hours
- •Exclusion Criteria
- •Klebsiella infection, susceptible to carbapenems
- •Duration of antimicrobial therapy less than 72 hours
- •Data not completely available from the electronically medical chart
排除标准
- 未提供
结局指标
主要结局
28-day mortality
时间窗: 28 day
mortality after 28 day from infection
次要结局
未报告次要终点
研究者
Dr. Gennaro De Pascale
MD
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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