Diagnostic Value of Transcranial Doppler Ultrasound for Evaluating Neonatal Craniocerebral Injuries
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Sensitivity of transcranial Doppler ultrasound
研究概览
简要总结
This study aims to evaluate the diagnostic value of transcranial Doppler ultrasonography (TCD) for evaluating neonatal craniocerebral injuries.
详细描述
A high-risk neonate refers to an infant, irrespective of gestational age or birth weight, who exhibits an elevated likelihood of experiencing health complications or death. Preterm infants, defined as those born alive at a gestational age of less than 37 weeks, have seen increased birth and survival rates due to advancements in medical technology and the widespread establishment of Neonatal Intensive Care Units (NICUs).
Neonatal sepsis is one of the leading causes of morbidity and mortality among term and preterm infants worldwide.
Transcranial Doppler ultrasonography (TCD) is the only noninvasive method that enables reliable evaluation of blood flow in the basal intracerebral vessels, providing physiological information complementary to anatomic imaging. TCD is relatively inexpensive, can be performed at the bedside, and enables monitoring in acute emergency settings and for prolonged periods with high temporal resolution, making it ideal for studying dynamic cerebrovascular responses.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 37 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Both sexes.
- •High-risk neonates with any of the following:
- •Critically ill neonates.
- •Neonatal sepsis.
- •Neonatal encephalopathy includes hypoxic-ischemic encephalopathy.
- •Respiratory distress.
- •Neonatal seizures.
- •Birth asphyxia.
- •Signs and or symptoms of central nervous system disorders like microcephaly, macrocephaly, hypotonia, unexplained poor feeding,
- •Neonates born out of traumatic/instrumental labor.
- •Suspected metabolic disturbances.
- •Neonates with low APGAR score (<7).
- •Neonates with low birth weight (<2.5 kg).
排除标准
- •Congenital malformations.
- •Genetic metabolic diseases or other severe complications.
- •Severe intrauterine infection.
研究组 & 干预措施
Group A
High-risk neonates with confirmed risk factor.
干预措施: Transcranial Doppler ultrasound (Device)
Group B
Healthy neonates without any identified risk factor, matched to Group A for age and sex.
干预措施: Transcranial Doppler ultrasound (Device)
结局指标
主要结局
Sensitivity of transcranial Doppler ultrasound
时间窗: 6 months post-procedure
The sensitivity of transcranial Doppler ultrasound in diagnosing brain injury will be recorded
次要结局
未报告次要终点
研究者
Neamat Mohamed Kamal Omar
Resident of Diagnostic and Intervention Radiology, Faculty of Medicine, Kafr- Elsheikh University
Kafrelsheikh University