NCT07816575已完成不适用
Comparative Efficacy of Alpha Hydroxy Acids With and Without Nanocarriers Versus Calcipotriol Plus Betamethasone in Treatment of Plaque Psoriasis
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Percentage Change in PASI Score.
研究概览
简要总结
The aim of this double blind comparative clinical study is to evaluate the efficacy of AHAs combined with nanocarriers and their use as a non steroidal alternative drug for long term management of plaque psoriasis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mid to moderate cases according to Psoriasis Area and Severity Index (PASI).
- •Age from18-65 years old.
- •Denovo psoriatic patients and patients with no psoriasis therapy in the previous two months.
排除标准
- •Severe irritation and highly inflamed skin.
- •Pregnant and lactating females.
- •Patients with acute renal insufficiency.
- •Face, flexural and groin lesions.
研究组 & 干预措施
Alpha Hydroxy Acids with Nanocarriers Group
Experimental
Patients received Alpha Hydroxy Acids formulated with nanocarriers.
干预措施: Alpha Hydroxy Acids with nanocarriers (Drug)
Alpha Hydroxy Acids Group.
Experimental
Patients received Alpha Hydroxy Acids only.
干预措施: Alpha Hydroxy Acids only. (Drug)
Placebo Group
Placebo Comparator
Patients received placebo comparator.
干预措施: Placebo. (Other)
Calcipotriol plus betamethasone Group.
Active Comparator
Patients received calcipotriol plus betamethasone.
干预措施: Calcipotriol plus betamethasone (Drug)
结局指标
主要结局
Percentage Change in PASI Score.
时间窗: Baseline and 8 weeks
Reduction in PASI score from baseline to week 8.
次要结局
- Dermatology Life Quality Index (DLQI)(Baseline and 8 weeks).)
研究者
Bodour Kamal Elshenawy
Resident
Al-Azhar University
研究点 (1)
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