Combining 4D MRI and 4DCT for Personalized Volumetric Motion Monitoring in Lung Radiation Therapy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- To investigate if time-resolved, multicycle volumetric motion modeling and monitoring gives improved spatiotemporal localization of the tumor target and OARs compared to current standard-of-care 4DCT-based motion modeling and monitoring
研究概览
简要总结
The purpose of this study is to assess a real time motion tracking of lung tumors and important organs next to the tumor while breathing during a participant's radiation treatment. This will be assessed through a four-dimensional magnetic resonance imaging (MRI) scan before starting your radiation treatment and x-ray fluoroscopy images that are taken during radiation
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult (≥18 years) patients (both sexes) with histologically diagnosed Stage II-IIIb NSCLC
- •Patients to be treated with definitive external beam photon radiotherapy with or without systemic therapy (e.g., chemotherapy, immunotherapy).
- •No restrictions on number radiotherapy fractions, or location/number of lesions
- •ECOG performance status ≤ 3
- •Ability to undergo MRI scans
- •Patient has signed informed consent document and agreed to study procedures
排除标准
- •Pre-existing contraindications for MRI, such as any MRI-conditional or MRI-unsafe foreign objects within the body, non-removable ear cochlear or eye implant, aneurysm clip, cardiac pacemaker/wires, internal defibrillator, tissue expander, recent stent placement, penile prosthesis, medication patch, artificial limb, pregnancy, and claustrophobia
- •Women who are pregnant or trying to get pregnant (self-reported)
- •Pain in supine position or inability to raise arm above head in supine position
研究组 & 干预措施
Imaging
At baseline, patients will receive a 4D CT Simulation (standard of care) along with a 4D MRI with surface monitoring (research).
During their radiation treatment, they will receive additional fluoroscopy imaging and surface monitoring.
干预措施: MRI (Other)
结局指标
主要结局
To investigate if time-resolved, multicycle volumetric motion modeling and monitoring gives improved spatiotemporal localization of the tumor target and OARs compared to current standard-of-care 4DCT-based motion modeling and monitoring
时间窗: 3 years
次要结局
未报告次要终点
研究者
Amit Sawant
Principal Investigator
University of Maryland, Baltimore