The Effect of Intravenous Lidocaine on Allodynia (Carl Koller Grant)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Pain Perception
研究概览
简要总结
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
详细描述
Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi
排除标准
- •History of Substance abuse
- •Other Medications: CRPS patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis.
- •Coronary Artery Disease (CAD): unstable
- •Congestive Heart Failure (CHF): unstable
- •Heart Arrhythmia: symptomatic
- •Chronic Obstructive Pulmonary Disease (COPD)
- •Lidocaine Allergy
- •Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation.
- •Presence of Contraindications for MRI
- •Presence of electronically, magnetically, and mechanically activated implants
- •Electronically, magnetically, and mechanically activated implants
- •Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators
- •Cardiac pacemakers
- •Metallic splinters in the eye
- •Ferromagnetic haemostatic clips in the central nervous system (CNS)
- •Claustrophobia
- •Pregnancy
研究组 & 干预措施
Lidocaine
Intravenous lidocaine for neuropathic pain
干预措施: lidocaine (Drug)
结局指标
主要结局
Pain Perception
时间窗: Participants will be followed from baseline through 128 minutes
Assessing heat pain perception (pain intensity) before, during, and after lidocaine infusion by means of patient self-report using a mechanical slide algometer. The mechanical slide algometer \[Price et al. (1994)\] looks like a ruler that exposes a red bar with the end-points: no pain (left) and most pain imaginable (right). The use the slider to express their perceived pain. On the back of the ruler a numerical scale ranging from 0 (no pain) to 10 (worst imaginable pain) translates the patient's rating into a numeric scale.
次要结局
未报告次要终点
研究者
Michael Froelich
Associate Proffesor Anesthesiology M.D.
University of Alabama at Birmingham