KCT0007518招募中未知
Effect and Safety of Chronotherapy Compared to Conventional therapy in the Elderly Patients with Nocturnal Hypertension
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 300
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 65(Year) 至 o Limit（—）
- 性别
- All
入选标准
- •Patients aged 65 or older with hypertension and enrolled in the targeted blood pressure study (HOWOLD-BP trial, 2018-09-015) in the treatment of hypertension among elderly hypertension subjects. 1) Patients whose blood pressure is controlled by taking stable doses in the last 3 months. 3) Among patients with confirmed night hypertension in blood pressure monitoring during activities, those who voluntarily agreed are targeted.
排除标准
- •It is the same as the exclusion criteria of the study on prognosis analysis according to target blood pressure when treating hypertension in elderly hypertension subjects (HOWOLD-BP trial, 2018-09-015). Patients who meet any of the following criteria cannot participate in this clinical trial.
- •1) Subjects with all suspected history of secondary hypertension, such as aortic stenosis, hyperaldosterone, renal stenosis, cushing disease, chromium-friendly cytoma, and polycystic nephrotic disease, and all suspected of secondary hypertension.
- •2) Resistant hypertension subjects whose blood pressure is controlled to less than 140/90 mmHg using three or more antithrombotic drugs, including diuretics, or four or more antithrombotic drugs including diuretics, with blood pressure controlled to less than 140/90 mmHg.
- •3) Subjects with orthostatic hypotension (One minute standing SBP < 110 mmHg) accompanied by symptoms at the time of screening
- •4) Subject to uncontrolled diabetes whose HbA1C value is defined to be 10% or higher at the time of screening.
- •5) Subject to chronic kidney disease with maintenance dialysis or estimated GFR 1515 mL/min/1.73 m2
- •6) Subjects who have undergone acute coronary syndrome, heart surgery, and urgent percutaneous coronary intervention (PCI) within the last 3 months.
- •7) Subject to systolic heart failure with a left ventricular uvula rate of less than 40% in the past history.
- •8) Subjects with hypertrophic obstructive cardiomyopathy, aortic stenosis, severe valve disease, and hemodynamically significant congenital heart disease.
- •9) Subject to acute stroke diagnosed with stroke within the last 3 months.
- •10) Subjects with known moderate or malignant retinopathy such as retinal bleeding, vision impairment, and retinal microarachnoid within the last 6 months.
- •11) Subjects who have clinically significant liver disease or whose AST/ALT level is 3 times or more than the normal upper limit.
- •12) Uncontrolled thyroid function.
- •13) Those who participated in other clinical trials within 4 weeks of screening or those who plan to participate in other clinical trials during this intervention study.
- •14) If there are other serious reasons for restricting participation and progress in research at the discretion of the researcher
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