Examining the Clinical Utility of Motion Immune MRI Across Multiple Patient Populations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Rating of image quality (based on 8 criteria) by multiple radiologists (blind to reconstruction method)
研究概览
简要总结
The purpose of this study is to evaluate our recently developed MRI reconstruction strategy for producing artifact-free neuro and abdominal MRI data. The new reconstruction strategies, including 1) REKAM and 2) MUSE, are capable of effectively removing motion-related artifacts resulting from global and local motion during neuro and free-breathing abdominal MRI scans, without modifying the MRI pulse sequences and protocols that are currently used in clinical scans. The study team aims to recruit 60 subjects across multiple challenge patient populations: 10 healthy young adults (age 20-30) and 10 healthy older adults (aged 50-70) for abdominal MRI, as well as 20 tremor dominant PD patients and 20 children (age 4-8) for brain MRI scans. There are no known risks in taking MRIs and a unique code will be assigned to each participant to protect their PHI.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •subject's age is within one of the following age ranges (4-8, 20-30, or 50-70 years old);
- •male or female;
- •healthy volunteer or diagnosed with PD ; and
- •devoid of the following exclusion criteria.
排除标准
- •claustrophobia or other MRI contraindications (including pregnancy);
- •diagnosis for dementia (Alzheimer's, Lewy Body, or Vascular);
- •symptomatic psychotic disorders;
- •depression with psychotic symptoms;
- •other psychotic or schizophrenic disorders;
- •recent neuroleptic treatment;
- •history of cardiovascular disease;
- •history of stroke or Transient Ischemic Attack;
- •cancer (other than skin cancer) within the last three years;
- •hospitalization for neurological/psychiatric condition;
- •significant handicaps (e.g., visual or hearing loss, mental retardation) that would interfere with neuropsychological testing or the ability to follow study procedures; or
- •any other factor that in the investigators' judgment may affect patient safety or compliance.
结局指标
主要结局
Rating of image quality (based on 8 criteria) by multiple radiologists (blind to reconstruction method)
时间窗: 1 day (At time of image analysis)
The ratings will be compared to compare the quality of images processed with MUSE versus conventional reconstruction methods
次要结局
未报告次要终点