Employing dynamic kinetic responses to demonstrate the effectiveness of dietary intervention: A challenge-based study using a low-glycaemic load diet - Metflex

niversiteit Maastricht0 个研究点目标入组 76 人开始时间: 待定最近更新: 2024年2月28日

试验速览

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•- Signed informed consent
•- Men and postmenopausal women: >= 50 and <= 70 years at the start of the study
•- Body mass index (BMI) >= 25.0 and <= 35.0 kg/m2
•- Healthy (as determined by dependent physician): no medical conditions which might affect the study measurements, absorption, metabolism and distribution (including diabetes type 1 and type 2, gastrointestinal dysfunction, gastrointestinal surgery and inflammatory diseases) as assessed by physical characteristics and health and lifestyle questionnaire
•- Fasting blood glucose value <= 6.9 mmol/litre at screening
•- Waist circumference >94 cm for males, >80 cm for females
•- Maximum 2.5 hours of moderate to vigorous physical activity per week (during last 3 months)
•- Agreeing to be informed about medically relevant personal test-results by a physician
•- Willing to comply to study protocol during study
•- Accessible veins on arms as determined by examination at screening

•- Reported participation in another nutritional or biomedical trial three months before the pre- study examination or during the study
•- Blood donation in the past three months
•- Reported participation in night shift work two weeks prior to pre-study investigation or during the study. Night work is defined as working between midnight and 6.00 AM
•- Consumption of > 21 alcoholic units for males, > 14 alcohol units for females in a typical week
•- Reported use of any nicotine containing products in the six months preceding the study and during the study itself
•- Reported dietary habits: medically prescribed diet, slimming diet, vegetarian
•- People who are familiar with an allergy or intolerance to any of the provided food products
•- Reported weight loss or weight gain (10%) in the last six months prior to the pre-study screening
•- Clinically relevant abnormalities in clinical chemistry at screening (to be judged by the study physician)
•- Being an employee of Unilever or the collaborating research departments in Maastricht University Medical Centre (MUMC+)
•- Taking medication, which may interfere with study measurements, as judged by the responsible physician
•- Subjects, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician is informed

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