The Effects of a 12- Week Combined Exercise Training Program on Arterial Stiffness, Endothelial Function, Inflammatory Markers and Metabolic Profile in Obese Adolescent Girls: A Pilot Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- Maximal heart rate
研究概览
简要总结
The purpose of this study was to examine the impact of 12 weeks of combined exercise training (CET) on arterial stiffness, endothelial function, inflammatory markers, insulin resistance, and body composition in obese adolescent girls. Thirty obese adolescent girls participated in this study. The girls were randomly divided into CET group (n=15) and control group (n=15). The CET group performed concurrent resistance training followed by aerobic training at 40-70% of the heart rate reserves (HRR) 3 days/week for 12 weeks. Plasma nitric oxide, endothelin-1, C-reactive protein, arterial stiffness, homeostasis model assessment of insulin resistance (HOMA-IR), glucose, insulin, and the adiponectin/leptin ratio were measured before and after the 12-weeks study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 16 Years（Child）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Obese with hyperinsulinemia
- •Abdominal obesity
- •Sedentary (no regular exercise training or physical activity)
- •No weight loss diet during last 6 months.
排除标准
- •Hypertension
- •Pregnancy
- •Chronic disease
研究组 & 干预措施
No Exercise (CON)
Fifteen obese adolescent girls. This arm did not perform any exercise training for 12 weeks. Caloric intake was 1921.7 kcal/day.
Combined Exercise Training (CET)
Fifteen obese adolescent girls. This arm performed combined exercise training 3 times per a week for 12 weeks. Caloric intake was 1921.7 kcal/day.
干预措施: Combined Exercise Training (Behavioral)
结局指标
主要结局
Maximal heart rate
时间窗: 12 weeks
Maximal heart rate was obtained at the end of a graded treadmill exercise test performed until volitional exhaustion.
Body fat
时间窗: 12 weeks
Percent body fat (%) was determined using a bioelectrical impedance-meter.
Insulin resistance
时间窗: 12 weeks
Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR).
Plasma adiponectin
时间窗: 12 weeks
Plasma adiponectin was measured using ELISA kit
Waist circumference
时间窗: 12 weeks
Waist circumference was measured at midpoint between the lower rib and the iliac crest at the end of a normal expiration using a tape measure
Nitric oxide
时间窗: 12 weeks
Nitric oxide generation was measured by Griess assay kit.
Endothelin-1
时间窗: 12 weeks
Levels of Endothelin-1 in blood were measured by Endothelin-1 enzyme immunoassay kit.
Body weight
时间窗: 12 weeks
Body weight was measured to nearest 0.1 kg.
Height
时间窗: 12 weeks
Height was measured to nearest 1 cm.
Arterial stiffness
时间窗: 12 weeks
Arterial stiffness was measured as measurement of baPWV (m/s).
Plasma leptin
时间窗: 12 weeks
Plasma leptin was determined by ELISA kit
次要结局
未报告次要终点
研究者
Won-mok son
Principal Investigator
Pusan National University