JPRN-UMIN000018045已完成未知
Research on Determining Normal Binding Extent of Dopamine Transporter Binding Ratio using 123I-FP-CIT SPECT - Normal Binding Extent of Dopamine Transporter Scintigraphy using 123I-FP-CIT SPECT
Department of Neurology,Juntendo University0 个研究点目标入组 40 人开始时间: 2015年6月30日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
A strong correlation between the SBR and age was observed. The correlation coefficient in males and females were -0.566 and -0.502, respectively. The analysis of variance revealed that aging led to a decline of the SBR, and a significant difference (p=0.005) was observed among generations. Gender also affected the SBR, and there was a significant difference between males and females (p=0.036). The SBR in females was higher than in males. Consequently, the multiple comparison revealed a significant difference between 50s and 70s (p=0.015) and 50s and 80s (p=0.006).
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 50years-old 至 90years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) Individuals who are pregnant, possibly pregnant, or lactating 2) Individuals with past history of alcoholism, or alcoholics currently under treatment 3) Individuals with past history of epilepsy, or epileptics currently under treatment 4) Individuals with less than 6-year education 5) Individuals who are prescribed with antidepressant or psychotropics, or sedatives including anti-anxiety agents for a long time 6) Individuals with past history of mental or neurological illnesses which affect cognitive functions 7) Individuals with serious complications such as hepatopathy, nephropathy, or endocrinopathy 8) Individuals taking the below mentioned drugs that are considered to affect on accumulation of 123I FP-CIT in the brain within a month after administering the same: cocaine hydrochloride, mazindol, methylphenidate hydrochloride, sertraline hydrochloride, and selective serotonin reuptake inhibitor 9) Individuals judged inappropriate for accomplishing our objective by the principal investigator, researchers in charge, or cooperative researchers
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