NCT04507594已完成不适用
Measurement of Diaphragmatic Dysfunction in Patients Undergoing Thoracic Resection Surgery for Lung- or Esophageal Cancer
Aarhus University Hospital1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2020年8月6日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change in excursion of the diaphragm
研究概览
简要总结
This study aims to measure diaphragmatic dysfunction with ultrasonography and nerve stimulation of the phrenicus nerve, in patients undergoing thoracic surgery for lung and esophageal cancer, and correlate measures of diaphramatic function to clinical postoperative endpoints.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled thoracic resection Surgery for lung- or esophagus cancer. For lung cancer patients, at least one lung lobe has to scheduled for resection
排除标准
- •Known Diaphragmatic Dysfunction
- •Neuromuscular Disease
- •Pleural Effusion > 1cm
- •Pneumothorax
- •Known Phrenic Nerve Palsy
结局指标
主要结局
Change in excursion of the diaphragm
时间窗: Prior to surgery to 14 days after surgery
Ultrasonographic measure with M-mode of Diaphragmatic Excursion on right hemidiaphragm
次要结局
- Change in Diaphragmatic Thickening Fraction(Prior to surgery to 14 days after surgery)
- Change in peak flow(Prior to surgery to 14 days after surgery)
- Ultrasonographic measure of the difference in Intrathoracic Area(Prior to surgery to 14 days after surgery)
- Change in forced expired volume within the first second (FEV1)(Prior to surgery to 14 days after surgery)
- Change in Electromyographic measure of Maximal Diaphragmatic Response after stimulating the phrenic nerve(Prior to surgery to 14 days after surgery)
- Postoperative Pulmonary Complications(Prior to surgery to 30 days after surgery)
- Change in forced vital capacity (FEV)(Prior to surgery to 14 days after surgery)
- Change in Electromyographic measure of Latency of Diaphragmatic Response after stimulating the phrenic nerve(Prior to surgery to 14 days after surgery)
- Change in 6 Minutes Walk Test(Prior to surgery to 14 days after surgery)
- Accumulated Opiod Use after Surgery(Prior to surgery to 14 days after surgery)
- Admission days at the Intensive Care Unit after Surgery(Prior to surgery to 60 days after surgery)
- Accumulated Admission Days at any Hospital(Prior to surgery to 60 days after surgery)
- Change in Intercostal Muscle Thickening Fraction(Prior to surgery to 14 days after surgery)
- Change in visual analogue scale score(Prior to surgery to 14 days after surgery)
- Number of Admissions after Discharge from the Surgical Department(Prior to surgery to 60 days after surgery)
研究者
Peter Juhl-Olsen
Associate Professor
Aarhus University Hospital
研究点 (1)
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