Manual Cervical Traction and Trunk Stabilization Causes Significant Changes in Lower and Upper Esophageal Sphincter
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Pressure in upper and lower esophageal sphincter
研究概览
简要总结
The aim of this study is to test the influence of manual cervical traction and chest stabilization maneuvers on pressures in upper and lower esophageal sphincters.
详细描述
High Resolution Manometry (HRM) will be used to measure pressure changes in upper esophageal sphincter (UES) and lower esophageal sphincter (LES) during manual cervical traction and trunk stabilization maneuvers. 50-55 gastroesophageal reflux disease (GERD) subjects will participate in the study. UES and pressures will first be measured in relaxed supine position then, during manual cervical traction and finally, the subjects will undergo manual positioning of the trunk into neutral position and LES and UES pressures will be measured again.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gastroesophageal reflux disease
排除标准
- •Previous gastro- esophageal surgery
- •Concomitant other chronic disease that would affect esophageal motility
- •Esophageal structural pathology
- •Massive hiatus hernia
结局指标
主要结局
Pressure in upper and lower esophageal sphincter
时间窗: up to 6 months
Pressure in upper and lower esophageal sphincter at rest, during cervical manual traction, and during trunk stabilization maneuver
次要结局
未报告次要终点
研究者
Alena Kobesova
Clinical Professor
University Hospital, Motol