SARS-COV-2 Seroprevalence and Seroconversion Among Employees of the Universitair Ziekenhuis Brussel During the 2020 COVID-19 Outbreak
试验速览
- 阶段
- 不适用
- 入组人数
- 3,500
- 试验地点
- 2
- 主要终点
- Seroprevalence
研究概览
简要总结
A novel zoonotic coronavirus was discovered in Wuhan (Hubei Province, China) mid-December 2019 and was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus rapidly spread to the rest of the world, including Europe and explicitly affects the respiratory system, generating Coronavirus disease 2019 (COVID-19).
This study is a monocentric interventional prospective cohort study. After signing a written informed consent, participants will be recruited for questionnaire completion and blood sampling. Sample storage and analysis will be performed at the laboratory of microbiology of the UZ Brussel.
- To document SARS-CoV-2 seroprevalence among employees of the UZ Brussel at day 0 (i.e. at beginning of the study, planned early May 2020), month 2 and month 5.
- To document number of SARS-CoV-2 seroconversions among employees of the UZ Brussel over a period of 5 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Any adult employee of the UZ Brussel who provided a signed informed consent to participate in the study.
排除标准
- •UZ Brussel employees whose contract expires within 6 months of study initiation, with the exception of resident trainees (if training continues in another hospital, resident trainees will be asked to perform the last sampling when leaving the UZ Brussel).
- •Staff not active during the inclusion period
结局指标
主要结局
Seroprevalence
时间窗: Change from baseline to 2 months and 5 months timepoint
- To document SARS-CoV-2 seroprevalence among employees of the UZ Brussel at day 0 (i.e. at beginning of the study, planned early May 2020), month 2 and month 5.
seroconversions
时间窗: Change from baseline to 2 months and 5 months timepoint
- To document number of SARS-CoV-2 seroconversions among employees of the UZ Brussel over a period of 5 months.
次要结局
- Incidence of probable cases(Change from baseline to 2 months and 5 months timepoint)
- Incidence of definite cases(Change from baseline to 2 months and 5 months timepoint)
- Antibody kinetics(Change from baseline to 2 months and 5 months timepoint)
- Proportion of asymptomatic seroconversions(Change from baseline to 2 months and 5 months timepoint)
- Concerns for safety for infection with COVID-19(Change from baseline to 2 months and 5 months timepoint)
- Potential work-related risk factors(Change from baseline to 2 months and 5 months timepoint)