ISRCTN49306926已完成不适用

Dynamics of endocrine and inflammatory changes during critical illness: An observational trial comparing patients and healthy volunteers

IWT Flanders (Agentschap voor Innovatie door Wetenschap en Techniek) (Belgium)0 个研究点目标入组 133 人开始时间: 2010年8月12日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•Intervention 1:
•1. Patients: all patients admitted to the surgical and medical intensive care units of the university hospitals, Leuven, (Belgium), will be screened for inclusion when they are still mechanically ventilated at the 2nd, 3rd or 4th day after admission, provided that they do not meet one of the exclusion criteria below.
•2. Healthy volunteers: Age-matched to the average age of the included patient population
•Added 25/10/2011:
•Intervention 2:
•1. Patients: all patients with a urinary catheter, present at the surgical and medical intensive care units of the university hospitals, Leuven (Belgium).
•2. Healthy volunteers: age-matched to the average age of the included patient population.
•Intervention 3:
•1. Patients: critically ill patients who died in the intensive care unit and who undergo an autopsy.
•2. Controls: non-critically ill persons who died in the emergency unit and who undergo an autopsy.
•Intervention 4:
•1. Patients: patients receiving a bolus injection of hydrocortisone based on clinical indications.
•2. Healthy volunteers: age matched to the average age of the included patient population.

•Intervention 1 and 2:
•1. Patients:
•1.1. Age < 18 years
•1.2. Do not resuscitate order
•1.3. No arterial line in place
•1.4. Patients expected to die within the next 24 hours
•1.5. Pregnancy
•1.6. Cerebral disease
•1.7. (pan)Hypopituitarism
•1.8. Known adrenal disease (Cushing or Addisson)
•1.9. Systemic treatment with corticosteroids within the last 3 months
•1.10. Etomidate within the last 72 hours
•1.11. Dopamine within the last 12 hours
•1.12. Vasopressine within the last 12 hours
•1.13. Treatment with an azole within the last 24 hours
•2. Healthy volunteers:
•2.1. Age <50 or >75 years
•2.2. Active malignancy
•2.3. Pregnancy
•2.4. Cerebral disease
•2.5. (pan)Hypopituitarism
•2.6. Known adrenal disease (Cushing or Addisson)
•2.7. Systemic treatment with corticosteroids within the last 3 months
•Added 25/10/2011:
•Intervention 3:
•1. Patients:
•1.1. Age < 18 years
•1.2. Cerebral disease
•1.3. (pan)hypopituitarism
•1.4. Known adrenal disease (Cushing or Addisson)
•1.5. Systemic treatment with corticosteroids within the last 3 months before death
•2. Controls
•2.1. Critical illness or chronic disease
•2.2. Cerebral disease
•2.3. Systemic treatment with corticosteroids within the last 3 months before death
•Intervention 4:
•1. Patients:
•1.1. Age < 18 years
•1.2. No arterial line in place
•1.3. Ascites
•2. Healthy volunteers:
•Same as for intervention 1

发起方

IWT Flanders (Agentschap voor Innovatie door Wetenschap en Techniek) (Belgium)