NCT05821400招募中不适用
Cognitive Changes in Mild Cognitive Impairment Without Orthostatic Hypotension
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Changes in Montreal Cognitive Assessment (MoCA) scores after 3 months.
研究概览
简要总结
Background: In recent years, the changes of cognitive function in mild cognitive impairment have attracted attention.
Methods/design: We will follow up at 3. The primary outcome will be the measurement of cognitive function using neuropsychological assessment scales such as MOCA, MMSE, etc... Minor variables will be included plasma biomarkers (Aβ, Tau, GFAP, etc.), multimodal brain electrophysiology (P300, VP300, heart rate variability, etc.), and neuroimaging indicators (NODDI).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinically diagnosed mild cognitive impairment
排除标准
- •Patients with orthostatic hypotension
- •Patients with other neurological disorders.
- •Pregnant or lactating women.
结局指标
主要结局
Changes in Montreal Cognitive Assessment (MoCA) scores after 3 months.
时间窗: Participants will be followed up for 3 months after baseline.
The MOCA scale scores range from 0 to 30, with higher scores indicating better cognition
次要结局
- Changes in Blood pressure (mmHg) after 3 months.(Participants will be followed up for 3 months after baseline.)
- Changes in Plasma tau levels after 3 months.(Participants will be followed up for 3 months after baseline.)
- Changes in Plasma amyloid protein levels after 3 months.(Participants will be followed up for 3 months after baseline.)
研究者
研究点 (1)
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